Neuropilin 1 antibody (FITC)

Catalog No. ABIN2661385

The Mouse Monoclonal anti-Neuropilin 1 antibody has been validated for FACS and ICFC. It is suitable to detect Neuropilin 1 in samples from Human.

Quick Overview for Neuropilin 1 antibody (FITC) (ABIN2661385)

Target: Neuropilin 1 (NRP1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuropilin 1 antibody is conjugated to FITC

Application: Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)

Clone: 12C2

Product Details anti-Neuropilin 1 Antibody (FITC)

Purification: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC and unconjugated antibody.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for Neuropilin 1

Target: Neuropilin 1 (NRP1)

Alternative Name: CD304

Background: CD304, also known as neuropilin-1, BDCA-4 and VEGF165R, is a 140 kD type I transmembrane protein. Its extracellular region contains 2 CUB, 2 FV/FVIII, and one MAM domain, a soluble isoform is produced by alternative mRNA splicing. CD304 is involved in angiogenesis, neural development, and tumor metastasis. It's expressed by plasmacytoid dendritic cells, thymocytes, neurons, endothelium, and a subset of TFH cells. CD304 is also expressed in several carcinomas, and a high expression of this molecule in prostate cancer correlates with a poor prognosis.

Pathways: Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals