CD276 antibody (PE)

Catalog No. ABIN2663287

The Rat Monoclonal anti-CD276 antibody has been validated for FACS. It is suitable to detect CD276 in samples from Mouse.

Quick Overview for CD276 antibody (PE) (ABIN2663287)

Target: CD276

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD276 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: RTAA15

Product Details anti-CD276 Antibody (PE)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CD276

Target: CD276

Alternative Name: CD276

Background: B7-H3 is a member of the B7 gene family. It has 88 % amino acid sequence identity with human B7-H3. It is mostly expressed on professional APCs, including B cells, macrophages, and dendritic cells. Its expression on dendritic cells appears to be up-regulated by LPS. B7-H3 protein inhibits T cell activation and cytokine production. It was reported that monoclonal antibody against B7-H3 enhanced T cell proliferation in vitro and led to exacerbated EAE in vivo. Therefore, B7-H3 may be a negative regulator on T cell activation and function.

Pathways: Cancer Immune Checkpoints