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Neuropilin 1 antibody

The Rat Monoclonal anti-Neuropilin 1 antibody has been validated for FACS. It is suitable to detect Neuropilin 1 in samples from Mouse.
Catalog No. ABIN2664541

Quick Overview for Neuropilin 1 antibody (ABIN2664541)

Target

See all Neuropilin 1 (NRP1) Antibodies
Neuropilin 1 (NRP1)

Reactivity

  • 116
  • 66
  • 57
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Mouse

Host

  • 124
  • 31
  • 4
  • 3
  • 1
Rat

Clonality

  • 117
  • 46
Monoclonal

Conjugate

  • 86
  • 22
  • 16
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Neuropilin 1 antibody is un-conjugated

Application

  • 125
  • 69
  • 47
  • 40
  • 35
  • 28
  • 15
  • 14
  • 13
  • 10
  • 4
  • 4
  • 1
  • 1
Flow Cytometry (FACS)

Clone

3E12
  • Purification

    The antibody was purified by affinity chromatography.

    Isotype

    IgG2a kappa
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Concentration

    0.5 mg/mL

    Buffer

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Storage Comment

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target

    Neuropilin 1 (NRP1)

    Alternative Name

    CD304

    Background

    CD304, also known as neuropilin-1, is a 140 kD type I transmembrane protein. Its extracellular region contains two CUB, two FV/FVIII, and one MAM domain. It is expressed by natural regulatory T cells (nTreg), a subset of invariant natural killer T cells (iNKT), endothelial cells, and neurons. Neuropilin-1 stabilizes the interaction between Tregs and dendritic cells, contributes to the recruitment of tumor-infiltrating Tregs in response to tumor-derived VEGF, and influences the process of angiogenesis and axon guidance. The ligands of CD304 are VEGF165 and semaphorin-3A.

    Pathways

    Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals
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