CD323 antibody

Catalog No. ABIN2664570

This anti- antibody is a Mouse Monoclonal antibody detecting in ELISA (Capture), IP, IHC and WB. Suitable for Human.

Quick Overview for CD323 antibody (ABIN2664570)

Target: CD323

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Application: ELISA (Capture), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)

Clone: SHM33

Product Details

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details

Target: CD323

Background: CD323, also known as JAM3 and JAM-C, is a member of the junctional adhesion molecule family and plays a role in leukocyte migration. It is a type I transmembrane protein and is involved in cell-cell adhesion by forming homotypic or heterotypic molecules with JAM family members or integrins. CD323 is expressed in intestinal epithelial cells and is a component of epithelial desmosomes, endothelial cells, and platelets. It is expressed at low levels on T cells and is upregulated upon activation. Due to their presence in tight junction and lateral membranes, JAMs are candidate receptors for leukocytes to use when they migrate. Thrombin induces localization of JAM3 in the tight junctions, whereas angiopoietin-1 prevents JAM3 localization.