IL-27/IL-35 EBI3 Subunit (Dimer), (Heterodimer), (Monomer) antibody

Catalog No. ABIN2665152

This Rat Monoclonal antibody specifically detects in FACS. It exhibits reactivity toward Mouse.

Quick Overview for IL-27/IL-35 EBI3 Subunit (Dimer), (Heterodimer), (Monomer) antibody (ABIN2665152)

Target: IL-27/IL-35 EBI3 Subunit

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Application: Flow Cytometry (FACS)

Clone: J053B5

Product Details

Binding Specificity: Dimer, Heterodimer, Monomer

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details

Target: IL-27/IL-35 EBI3 Subunit

Alternative Name: IL-27/IL-35 EBI3

Background: EBI3 is an IL-12 p40-related protein that can heterodimerized with IL-12 p35 to form IL-35, or with an IL-12 p35-related protein, p28, to form IL-27. It is produced by antigen-presenting cells such as B cells, monocytes, and dendritic cells (DCs) following stimulation through TLR. It can regulate T cell differentiation and proliferation. Both IL-27 and IL-35 are anti-inflammatory cytokines that are able to inhibit Th17 generation, promote Th1 differentiation, increase cytolytic activity of CD8+ T cells, and impact B cell differentiation and immunoglobulin production. IL-35 is also involved in tumorigenesis and is a promising biomarker for assessing tumor progression and prognosis in clinical settings.