IRF6 antibody

Catalog No. ABIN2665207

The Mouse Monoclonal anti-IRF6 antibody has been validated for WB. It is suitable to detect IRF6 in samples from Human.

Quick Overview for IRF6 antibody (ABIN2665207)

Target: IRF6 (Interferon Regulatory Factor 6 (IRF6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IRF6 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 14B2C16

Product Details anti-IRF6 Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for IRF6

Target: IRF6 (Interferon Regulatory Factor 6 (IRF6))

Alternative Name: IRF6

Background: IRF6 is a member of the IRF family of transcription factors, which are based on the presence of the conserved IRF tryptophan pentad repeat DNA-binding domain. Unlike other IRF transcription factors, IRF6 is not involved in the expression of interferon genes and doesn't seem to be involved in innate immunity. Data suggests that IRF6 is necessary for appropriate epidermal differentiation and development. Mutations of IRF6 are associated with human craniofacial developmental defects such as cleft lip, palate, tooth agenesis, Van der Woude syndrome, and popliteal pterygium syndrome. IRF6-deficient mice display severe morphological defects in skin and limbs, and result in perinatal lethality as well.