IL33RA antibody

Catalog No. ABIN2666013

This Rat Monoclonal antibody specifically detects IL33RA in FACS. It exhibits reactivity toward Mouse.

Quick Overview for IL33RA antibody (ABIN2666013)

Target: IL33RA (Interleukin 33 Receptor alpha (IL33RA))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Application: Flow Cytometry (FACS)

Clone: DIH4

Product Details anti-IL33RA Antibody

Characteristics: This product is produced with low endotoxin and is supplied azide free.

Purification: The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.

Sterility: 0.2 μm filtered

Endotoxin Level:

Endotoxin level is <0.01 EU/μg of the protein (<0.001 ng/μg of the protein) as determined by the LAL test.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Preservative: Azide free

Handling Advice: This Ultra-LEAF™ solution contains no preservative, handle under aseptic conditions

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for IL33RA

Target: IL33RA (Interleukin 33 Receptor alpha (IL33RA))

Alternative Name: IL-33R alpha

Background: IL-33Ra, also known as ST2 or IL-1RL1 is a member of the Toll/IL-1 receptor family. It binds IL-33 and is structurally similar to IL-1R1. Two forms of the protein exist - soluble form known as ST2 and membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells whereas the soluble form is expressed by serum-stimulated fibroblasts. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis has been reported to be important across a range of diseases including asthma, allergies and cardiac disease.