BCL11B antibody

Catalog No. ABIN2666299

The Rat Monoclonal anti-BCL11B antibody has been validated for FACS. It is suitable to detect BCL11B in samples from Human.

Quick Overview for BCL11B antibody (ABIN2666299)

Target: BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This BCL11B antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 25B6

Product Details anti-BCL11B Antibody

Cross-Reactivity: Mouse (Murine), Zebrafish

Cross-Reactivity (Details): Mouse, Zebrafish

Purification: Protein G affinity purified.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Hepes-buffered solution, pH 7.5, 0.02 % Sodium azide .

Storage: 4 °C

Storage Comment: Upon receipt, store undiluted between 2°C and 8°C.

Target Details for BCL11B

Target: BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))

Alternative Name: Bcl11b

Background: The transcription factor Bcl11b is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.