Ataxin 3 antibody

Catalog No. ABIN2666310

This Mouse Monoclonal antibody specifically detects Ataxin 3 in WB. It exhibits reactivity toward Human.

Quick Overview for Ataxin 3 antibody (ABIN2666310)

Target: Ataxin 3 (ATXN3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ataxin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1H9-2

Product Details anti-Ataxin 3 Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Upon receipt, store undiluted between 2°C and 8°C.

Target Details for Ataxin 3

Target: Ataxin 3 (ATXN3)

Alternative Name: Ataxin-3

Background: Ataxin-3 is an ubiquitously expressed protein which contains a poly-glutamine tract. Genetically abnormal expansion of the poly-glutamine repeats results in accumulation of ubiquitinated ataxin-3 protein aggregates and leads to a neurodegenerative disorder, Machado-Joseph disease (MJD). The protein has ubiquitin interacting motifs and a N-terminal Cysteine residue (C14) responsible for its deubiquitinating activity. Ataxin-3 binds and hydrolyzes polyubiquitinated proteins, and interacts with key proteasome components, such as p97/VCP and p45, indicating that Ataxin-3 may play functional roles in ubiquitin-proteasome system. The protein also act as a transcriptional repressor when interacting with transcriptional activators and coactivators.