CD1d antibody

Catalog No. ABIN2689065

There are 2+ publications for this product available. The Mouse Monoclonal anti-CD1d antibody is suitable to detect CD1d in samples from Human. It has been validated for FACS.

Quick Overview for CD1d antibody (ABIN2689065)

Target: CD1d (CD1D) (CD1d Molecule (CD1D))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD1d antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: CD1d42

Product Details anti-CD1d Antibody

Characteristics: Reacts with a glycosylated type I transmembrane α chain (43-49 kDa) non- covalently associated with β2-microglobulin. CD1d is a member of the CD1 family of molecules, which belong to the immunoglobulin superfamily. Sequence homology data classifies the CD1 Molecules into two groups. Group 1 includes CD1a, CD1b and CD1c molecules, group 2 includes CD1d molecules and their homologues in other species. CD1d is expressed on human intestinal epithelial cells (IEC). CD1d42 monoclonal antibody reacts with peripheral blood B cells coexpressing CD19 and CD45RA. It is not seen on CD3[+], or CD45RO[+] cells. Studies suggest that CD1d participates in lipid antigen presentation. Profile of peripheral blood lymphocytes analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD1d - Purified - Clone CD1d42 (also known as 42.1) - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-CD1d antibody (ABIN2689065)

Hong, Scherer, Singh, Mendiratta, Serizawa, Koezuka, Van Kaer: "Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice." in: Immunological reviews, Vol. 169, pp. 31-44, (1999) (PubMed).

Somnay-Wadgaonkar, Nusrat, Kim, Canchis, Balk, Colgan, Blumberg: "Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form." in: International immunology, Vol. 11, Issue 3, pp. 383-92, (1999) (PubMed).

Target Details for CD1d

Target: CD1d (CD1D) (CD1d Molecule (CD1D))

Alternative Name: CD1d

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process