CD81 antibody

Catalog No. ABIN2689415

This Mouse Monoclonal antibody specifically detects CD81 in FACS. It exhibits reactivity toward Human, Rabbit and Dog and has been mentioned in 2+ publications.

Quick Overview for CD81 antibody (ABIN2689415)

Target: CD81

Reactivity: Human, Rabbit, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD81 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: JS

Product Details anti-CD81 Antibody

Brand: BD Pharmingen™

Characteristics: JS-81 identifies the newly clustered CD81 antigen, a 26 kDa, type III transmembrane protein (also known as TAPA-1) that is involved in cell growth and signal transduction. CD81 has a very broad cellular distribution, being expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin. MAbs to CD81 have been shown to have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. Immunoprecipitation studies reveal that CD81 is a component of a multimolecular complex which can include the Leu13 Molecule, and the CD19 and CD21 Molecules in B cells. MAbs to CD81 are reported to induce homotypic cell aggregation. Profile of peripheral blood lymphocytes analyzed on a FACScan

BD Pharmingen™ Purified Mouse Anti-Human CD81 - Purified - Clone JS-81 - Isotype Mouse IgG1, κ - Reactivity Hu, Dog, Rab - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-CD81 antibody (ABIN2689415)

Schick, Levy: "The TAPA-1 molecule is associated on the surface of B cells with HLA-DR molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 8, pp. 4090-7, (1993) (PubMed).

Oren, Takahashi, Doss, Levy, Levy: "TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins." in: Molecular and cellular biology, Vol. 10, Issue 8, pp. 4007-15, (1990) (PubMed).

Target Details for CD81

Target: CD81

Alternative Name: CD81

Background: Synonyms: TAPA-1

Pathways: Inositol Metabolic Process, Hepatitis C