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Cadherin 13 antibody

This Rabbit Polyclonal antibody specifically detects Cadherin 13 in WB, IF, IHC (p) and EIA. It exhibits reactivity toward Human, Mouse and Rat.
Catalog No. ABIN272293

Quick Overview for Cadherin 13 antibody (ABIN272293)

Target

See all Cadherin 13 (CDH13) Antibodies
Cadherin 13 (CDH13)

Reactivity

Human, Mouse, Rat

Host

  • 103
  • 6
  • 2
  • 1
Rabbit

Clonality

  • 97
  • 15
Polyclonal

Conjugate

  • 57
  • 15
  • 9
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Cadherin 13 antibody is un-conjugated

Application

  • 78
  • 60
  • 34
  • 27
  • 20
  • 16
  • 14
  • 13
  • 12
  • 11
  • 4
  • 3
  • 3
  • 3
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • Specificity

    This antibody detects endogenous levels of T-Cadherin protein. (region surrounding Met352)

    Cross-Reactivity (Details)

    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.

    Purification

    Affinity Chromatography using epitope-specific immunogen
  • Application Notes

    ELISA: 1/20000approx. 1/40000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunofluorescence: 1/50approx. 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Restrictions

    For Research Use only
  • Concentration

    1.0 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freezing and thawing.

    Storage

    4 °C/-20 °C

    Storage Comment

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target

    Cadherin 13 (CDH13)

    Alternative Name

    Cadherin-13

    Background

    The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including β-catenin, to regulate cadherin function. T-cadherin (for truncated-cadherin, also designated heartcadherin or cadherin-13) expression levels have been shown to be reduced in human breast cancers and carcinoma cells lines. Evidence suggests that decreased levels of T-cadherin indicate a progression in breast malignancies.Synonyms: CDH13, CDHH, Cadherin H, Cadherin T, H-Cadherin, Heart cadherin, P105, T-Cadherin, Truncated cadherin

    Molecular Weight

    approx. 78 kDa

    Gene ID

    1012

    NCBI Accession

    NP_001248

    UniProt

    P55290

    Pathways

    EGFR Signaling Pathway, Cell-Cell Junction Organization
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