PRKAR1A antibody

Catalog No. ABIN2729578

Product Details anti-PRKAR1A Antibody

Target: PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRKAR1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full-length protein expressed in 293T cell transfected with human PRKAR1A expression vector

Clone: 6C7

Isotype: IgG1

Application Details

Application Notes: WB 1:2000, IHC 1:50, IF 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS ( pH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

References for anti-PRKAR1A antibody (ABIN2729578)

Graham, Lackner, Terracciano, González-Cantú, Maleszewski, Greipp, Simon, Torbenson: "Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1-PRKACA fusion." in: Hepatology (Baltimore, Md.), Vol. 68, Issue 4, pp. 1441-1447, (2019) (PubMed).

Graham, Terracciano, Meves, Vanderboom, Dasari, Yeh, Torbenson, Cruise: "Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 29, Issue 6, pp. 607-15, (2018) (PubMed).

Sousa, Gomez, Diniz, Bernardes, Soares, Brito, Liu, Pontes, Stratakis, Gomes: "Defects of the Carney complex gene (PRKAR1A) in odontogenic tumors." in: Endocrine-related cancer, Vol. 22, Issue 3, pp. 399-408, (2015) (PubMed).

Maleszewski, Larsen, Kip, Castonguay, Edwards, Carney, Kipp: "PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors." in: The American journal of surgical pathology, Vol. 38, Issue 8, pp. 1079-87, (2014) (PubMed).

Wells, OReilly, Szul, Sullivan, Handley, Garrett, McNicholas, Roda, Miller, Tal-Singer, Gaggar, Rennard, Jackson, Blalock: "An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease." in: American journal of respiratory and critical care medicine, Vol. 190, Issue 1, pp. 51-61, (2014) (PubMed).

Shajahan-Haq, Cook, Schwartz-Roberts, Eltayeb, Demas, Warri, Facey, Hilakivi-Clarke, Clarke: "MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer." in: Molecular cancer, Vol. 13, pp. 239, (2014) (PubMed).

Zhao, Li, Wohlford-Lenane, Agnihothram, Fett, Zhao, Gale, Baric, Enjuanes, Gallagher, McCray, Perlman: "Rapid generation of a mouse model for Middle East respiratory syndrome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 13, pp. 4970-5, (2014) (PubMed).

Tian, Jiang, Tamosiuniene, Sung, Qian, Dhillon, Gera, Farkas, Rabinovitch, Zamanian, Inayathullah, Fridlib, Rajadas, Peters-Golden, Voelkel, Nicolls: "Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension." in: Science translational medicine, Vol. 5, Issue 200, pp. 200ra117, (2013) (PubMed).

Wang, Henry, Distefano, Wang, Räikkönen, Mönkkönen, Tanaka, Morita: "Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human V?2V?2 T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 3, pp. 1029-42, (2013) (PubMed).

Target Details for PRKAR1A

Target: PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))

Alternative Name: PRKAR1A (PRKAR1A Products)

Molecular Weight: 43.0 KDa

Gene ID: 5573

NCBI Accession: NM_212472

HGNC: 5573

Pathways: Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma