PRKAR1A antibody

Catalog No. ABIN1944928

This Rabbit Polyclonal antibody specifically detects PRKAR1A in WB. It exhibits reactivity toward Human, Rat and Mouse. It has been mentioned in 4+ publications

Quick Overview for PRKAR1A antibody (ABIN1944928)

Target: PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRKAR1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PRKAR1A Antibody

Isotype: IgG

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-PRKAR1A antibody (ABIN1944928)

Solberg, Sandberg, Natarajan, Torjesen, Hansson, Jahnsen, Taskén: "The human gene for the regulatory subunit RI alpha of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase: two distinct promoters provide differential regulation of alternately spliced messenger ribonucleic acids." in: Endocrinology, Vol. 138, Issue 1, pp. 169-81, (1997) (PubMed).

Jones, Shapero, Chevrette, Fournier: "Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A." in: Cell, Vol. 66, Issue 5, pp. 861-72, (1991) (PubMed).

Sandberg, Skålhegg, Jahnsen: "The two mRNA forms for the type I alpha regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals." in: Biochemical and biophysical research communications, Vol. 167, Issue 1, pp. 323-30, (1990) (PubMed).

Sandberg, Taskén, Oyen, Hansson, Jahnsen: "Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis." in: Biochemical and biophysical research communications, Vol. 149, Issue 3, pp. 939-45, (1988) (PubMed).

Target Details for PRKAR1A

Target: PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))

Background: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.

Molecular Weight: 42982 Da

Gene ID: 5573

UniProt: P10644

Pathways: Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma