PRKAR1A Products
(Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
Categories
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013].
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Featured PRKAR1A Categories
PRKAR1A Antibodies
High quality antibodies with extensive validation data.
PRKAR1A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PRKAR1A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (5)
Cat. No.
ABIN3021148
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6264423
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
- (2)
Cat. No.
ABIN544271
Quantity
400 μL
Datasheet
Datasheet
Recommended PRKAR1A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648035
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730540
Quantity
96 tests
Datasheet
Datasheet
Recommended PRKAR1A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316243
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316241
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3082472
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PRKAR1A products
: "Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1-PRKACA fusion." in: Hepatology (Baltimore, Md.), Vol. 68, Issue 4, pp. 1441-1447, (2019) (PubMed).: "Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 29, Issue 6, pp. 607-15, (2018) (PubMed).
: "Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-κB signaling by targeting MAVS complex." in: Scientific reports, Vol. 6, pp. 33557, (2016) (PubMed).
: "Defects of the Carney complex gene (PRKAR1A) in odontogenic tumors." in: Endocrine-related cancer, Vol. 22, Issue 3, pp. 399-408, (2015) (PubMed).
: "PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors." in: The American journal of surgical pathology, Vol. 38, Issue 8, pp. 1079-87, (2014) (PubMed).
: "An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease." in: American journal of respiratory and critical care medicine, Vol. 190, Issue 1, pp. 51-61, (2014) (PubMed).
: "MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer." in: Molecular cancer, Vol. 13, pp. 239, (2014) (PubMed).
: "Rapid generation of a mouse model for Middle East respiratory syndrome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 13, pp. 4970-5, (2014) (PubMed).
: "Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension." in: Science translational medicine, Vol. 5, Issue 200, pp. 200ra117, (2013) (PubMed).
: "Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human V?2V?2 T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 3, pp. 1029-42, (2013) (PubMed).
Synonyms and alternative names related to PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A), protein kinase, cAMP dependent regulatory, type I, alpha (Prkar1a), protein kinase cAMP-dependent type 1 regulatory subunit alpha (Prkar1a), protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a (prkar1aa), cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene (LOC707275), protein kinase cAMP-dependent type I regulatory subunit alpha (Prkar1a), protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog (prkar1a.S), 1300018C22Rik, ACRDYS1, ADOHR, CAR, CNC, CNC1, cnc1, im:7047729, PKR1, pkr1, PPNAD1, ppnad1, PRKAR1, prkar1, prkar1a, RIalpha, RIIA, Tse-1, TSE1, Tse1, tse1, zgc:92515Protein level used designations for PRKAR1A
- cAMP-dependent protein kinase regulatory subunit RIalpha
- cAMP-dependent protein kinase type I-alpha regulatory chain
- cAMP-dependent protein kinase type I-alpha regulatory subunit
- protein kinase A type 1a regulatory subunit
- tissue-specific extinguisher 1
- protein kinase, cAMP dependent regulatory, type 1, alpha
- protein kinase, cAMP dependent regulatory, type I, alpha
- cAMP-dependent protein kinase type I regulatory subunit
- protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
- cAMP-dependent protein kinase, regulatory subunit alpha 1
- cAMP-dependent protein kinase regulatory subunit alpha 1
- cAMP-dependent protein kinase type I-alpha regulatory subunit-like
- protein kinase, cAMP-dependent, regulatory subunit type I alpha S homeolog
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