FBLN3 antibody

Catalog No. ABIN2763849

This anti-FBLN3 antibody is a Rabbit Polyclonal antibody detecting FBLN3 in WB, IHC and EIA. Suitable for Human.

Quick Overview for FBLN3 antibody (ABIN2763849)

Target: FBLN3 (Fibulin 3 (FBLN3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBLN3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Enzyme Immunoassay (EIA)

Product Details anti-FBLN3 Antibody

Cross-Reactivity: Human

Characteristics: EGF-containing fibulin-like extracellular matrix protein 1, Extracellular protein S1-5, Fibulin-like protein, EFEMP1,Fibulin-1 is a modular glycoprotein component of elastic extracellular matrix fibers, basement membranes and blood. It can bind calcium, Fibronectin, Laminin, Nidogen and Fibrinogen. Estrogen exposure to ovarian cancer cell lines can upregulate Fibulin-1. Fibulin-2 is abundant in heart, placenta and ovarian tissue and binds several components of the extracelllar matrix including aggrecan, versican and brevican. Fibulin-3, also known as EFEMP1, is a secreted protein. Defects in the gene for Fibulin-3 cause the autosomal dominant disease Doyne honeycomb retinal dystrophy (DHRD, also known as malattia leventinese) which is characterized by yellow-white deposits (drusen) that accumulate under the retinal pigment epithelium. Fibulin-3 is not present at the site of drusen formation in normal eyes. Fibulin-5 is an integrin-binding extracellular matrix protein that mediates endothelial cell adhesion.

Purification: Antigen Immunoaffiinity Purification

Immunogen: Synthetic peptide derived from human fibulin-3 protein

Isotype: IgG

Application Details

Application Notes: Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for FBLN3

Target: FBLN3 (Fibulin 3 (FBLN3))

Alternative Name: Fibulin-3

UniProt: Q12805

Pathways: EGFR Signaling Pathway