GAN antibody (Middle Region)

Catalog No. ABIN2774225

This Rabbit Polyclonal antibody specifically detects GAN in WB. It exhibits reactivity toward Human, Rat, Mouse, Cow, Dog, Rabbit, Guinea Pig and Horse.

Quick Overview for GAN antibody (Middle Region) (ABIN2774225)

Target: GAN (Gigaxonin (GAN))

Reactivity: Human, Rat, Mouse, Cow, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAN antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GAN Antibody

Binding Specificity: Middle Region

Sequence: IYLNDQNLCI PASSSFVYGA VPIGASIYVI GDLDTGTNYD YVREFKRSTG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GAN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GAN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 597 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GAN

Target: GAN (Gigaxonin (GAN))

Alternative Name: GAN

Background: This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN).
Alias Symbols: FLJ38059, GAN1, KLHL16
Protein Interaction Partner: RELA, HSP90AA1, CUL3, UBA1, TBCB, UBC, ATG16L1, RBX1, MAP1B, SFN,
Protein Size: 597

Molecular Weight: 66 kDa

Gene ID: 8139

NCBI Accession: NM_022041, NP_071324

UniProt: Q9H2C0