GJA1 antibody (Gap Junction Protein, alpha 1, 43kDa) (Middle Region) Primary Antibody
GJA1 Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat WB Host: Rabbit Polyclonal
Catalog No. ABIN2774852
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- Binding Specificity
- Middle Region
- Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
- This GJA1 antibody is un-conjugated
- Western Blotting (WB)
- Blocking Peptide
- Blocking peptide for this product available: ABIN977414
- GSTISNSHAQ PFDFPDDNQN SKKLAAGHEL QPLAIVDQRP SSRASSRASS
- Predicted Reactivity
- Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 93%
- This is a rabbit polyclonal antibody against GJA1. It was validated on Western Blot using a cell lysate as a positive control.
- Affinity Purified
- The immunogen is a synthetic peptide directed towards the middle region of human GJA1
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
Antigen size: 382 AA
- For Research Use only
- Lot specific
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Alternative Name
- GJA1 (GJA1 Antibody Abstract)
- Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5. This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CX43, DFNB38, GJAL, ODDD, HSS, AVSD3, HLHS1
Protein Interaction Partner: UBC, STAMBP, EPS15, UBQLN4, PSMD4, PSMD2, S100A1, GJA1, CNST, NEDD4, TJP1, HGS, TSG101, SGSM3, GJA5, MAPK7, MAPK3, CAV1, CSNK1D, SRC, PRKCG, PRKCE, PRKCB, PRKCA, MAPK1, NOV, CSK, GJA3,
Protein Size: 382
- Molecular Weight
- 43 kDa
- Gene ID
- NCBI Accession
- NM_000165, NP_000156
- MAPK Signaling, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization
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