HELLS antibody (Middle Region)

Catalog No. ABIN2775238

This Rabbit Polyclonal antibody specifically detects HELLS in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Dog, Horse, Cow and Guinea Pig.

Quick Overview for HELLS antibody (Middle Region) (ABIN2775238)

Target: HELLS (Helicase, Lymphoid-Specific (HELLS))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HELLS antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HELLS Antibody

Binding Specificity: Middle Region

Sequence: QSGLNLSKNF LDPKELMELL KSRDYEREIK GSREKVISDK DLELLLDRSD

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against HELLS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HELLS

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 838 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HELLS

Target: HELLS (Helicase, Lymphoid-Specific (HELLS))

Alternative Name: HELLS

Background: HELLS is a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis.This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Alias Symbols: FLJ10339, LSH, Nbla10143, PASG, SMARCA6
Protein Interaction Partner: UBC, VCP, APP, SUMO2, E2F3, SMARCAD1, MYC, HDAC2, HDAC1, DNMT3B, DNMT1, RPAP2, RPAP3,
Protein Size: 838

Molecular Weight: 92 kDa

Gene ID: 3070

NCBI Accession: NM_018063, NP_060533

UniProt: Q9NRZ9

Pathways: Chromatin Binding