RRN3 antibody (Middle Region)

Catalog No. ABIN2775808

This Rabbit Polyclonal antibody specifically detects RRN3 in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Guinea Pig, Cow, Dog and Horse.

Quick Overview for RRN3 antibody (Middle Region) (ABIN2775808)

Target: RRN3 (RRN3 RNA Polymerase I Transcription Factor (RRN3))

Reactivity: Human, Mouse, Rat, Rabbit, Guinea Pig, Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRN3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RRN3 Antibody

Binding Specificity: Middle Region

Sequence: VDGKVDNGKT KDLYRDLINI FDKLLLPTHA SCHVQFFMFY LCSFKLGFAE

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against RRN3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RRN3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 650 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RRN3

Target: RRN3 (RRN3 RNA Polymerase I Transcription Factor (RRN3))

Alternative Name: RRN3

Background: In mammals, growth-dependent regulation of RNA polymerase I (Pol I) transcription is mediated by RRN3, an essential initiation factor. It interacts with Pol I in the absence of template DNA, augments Pol I transcription in vivo and rescues transcription in extracts from growth-arrested cells in vitro.
Alias Symbols: TIFIA, A-270G1.2
Protein Interaction Partner: UBC, ACTA1, Polr1e, POLR1B, EIF3L, NMI, RBM15, UBD, Trim28, ELAVL1, TAF1D, POLR1A, MYO1C, TAF1C, TAF1B, TAF1A, UBTF, TBP, PPP2R2A, CDK2, CCNE1, RIBIN, ACTB,
Protein Size: 650

Molecular Weight: 74 kDa

Gene ID: 54700

NCBI Accession: NM_018427, NP_060897

UniProt: Q9NYV6

Pathways: Negative Regulation of intrinsic apoptotic Signaling