NMDAR2A antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a) (Middle Region)

Details for Product anti-GRIN2A Antibody No. ABIN2776120
Antigen
  • NMDAR2A
  • nr2a
  • GRIN2A
  • EPND
  • GluN2A
  • NR2A
  • glutamate ionotropic receptor NMDA type subunit 2A
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog
  • glutamate receptor ionotropic, NMDA 2A
  • glutamate receptor, ionotropic, NMDA2A (epsilon 1)
  • GRIN2A
  • grin2a.L
  • LOC100438553
  • Grin2a
Alternatives
anti-Human NMDAR2A antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
Middle Region
118
57
27
19
17
15
9
9
8
8
8
7
7
5
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rat (Rattus)
270
218
216
6
3
3
1
1
1
1
1
Host
Rabbit
198
137
1
Clonality
Polyclonal
Conjugate
This NMDAR2A antibody is un-conjugated
21
17
15
12
10
10
8
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
264
204
76
67
59
43
33
26
20
18
3
3
2
2
Options
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human GRIN2A
Blocking Peptide Blocking peptide for this product available: ABIN977683
Sequence DKIYTIDGEK EPGFHLDPPQ FVENVTLPEN VDFPDPYQDP SENFRKGDST
Predicted Reactivity Cow: 77%, Dog: 93%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 79%, Rat: 79%
Characteristics This is a rabbit polyclonal antibody against GRIN2A. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Plasmids, Primers & others Plasmids, Primers & others NMDAR2A products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name GRIN2A (GRIN2A Antibody Abstract)
Background N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D).N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: NMDAR2A, NR2A, EPND, GluN2A
Protein Interaction Partner: Nedd4, SPTAN1, DLG4, DLG1, UBC, GRIN1, ARHGAP32, CAMK2B, GRIN3B, GRIN3A, DLGAP1, CAMK2A, DLG2, AP1M1, INADL, IL16, AP4M1, RGS3, PTK2B, DLG3, CASK, SRC, PRKCA, PTPN4, PLCG1, GRIN2A, FYN, CDK5, ACTN1, Dlgap2,
Protein Size: 1464
Molecular Weight 163 kDa
Gene ID 2903
NCBI Accession NM_000833, NP_000824
UniProt Q12879
Pathways Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1464 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) (Middle Region) antibody (ABIN2776120) WB Suggested Anti-GRIN2A Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Pos...
Immunohistochemistry (IHC) image for anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) (Middle Region) antibody (ABIN2776120) Sample Type : Rat Hippocampal Neurons - 14DIV Primary Antibody Dilution : 1:200 S...
Background publications Kim, Chang, Nagpal, Yamashita, Baek, Dasgupta, Wu, Osada, Woo, Westra, Trink, Ratovitski, Moon, Sidransky: "The N-methyl-D-aspartate receptor type 2A is frequently methylated in human colorectal carcinoma and suppresses cell growth." in: Oncogene, Vol. 27, Issue 14, pp. 2045-54, 2008 (PubMed).

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