KLF6 antibody (Middle Region)

Catalog No. ABIN2776377

The Rabbit Polyclonal anti-KLF6 antibody has been validated for WB. It is suitable to detect KLF6 in samples from Human, Mouse, Rat, Dog, Horse, Guinea Pig, Rabbit and Cow.

Quick Overview for KLF6 antibody (Middle Region) (ABIN2776377)

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Reactivity: Human, Mouse, Rat, Dog, Horse, Guinea Pig, Rabbit, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLF6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KLF6 Antibody

Binding Specificity: Middle Region

Sequence: SREPSQLWGC VPGELPSPGK VRSGTSGKPG DKGNGDASPD GRRRVHRCHF

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against KLF6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KLF6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 283 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KLF6

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Alternative Name: KLF6

Background: KLF6 is a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. KLF6 may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes.This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: GBF, ZF9, BCD1, CBA1, CPBP, PAC1, ST12, COPEB
Protein Interaction Partner: UBC, APP, LCOR, SP1, NUFIP1, NOP56, TAF9, FBL, HDAC3, E2F1, NR0B2, PNO1, POLA2, GTF3C1, EHMT2, APOM, CELSR2, KLF4, TP53, CCND1,
Protein Size: 283

Molecular Weight: 32 kDa

Gene ID: 1316

NCBI Accession: NM_001300, NP_001291

UniProt: Q99612