ELAC2 antibody (C-Term)

Catalog No. ABIN2776757

This Rabbit Polyclonal antibody specifically detects ELAC2 in WB. It exhibits reactivity toward Human, Mouse, Rat and Dog.

Quick Overview for ELAC2 antibody (C-Term) (ABIN2776757)

Target: ELAC2 (ElaC Homolog 2 (ELAC2))

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELAC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ELAC2 Antibody

Binding Specificity: C-Term

Sequence: ITCNPEEFIV EALQLPNFQQ SVQEYRRSAQ DGPAPAEKRS QYPEIIFLGT

Predicted Reactivity: Dog: 100%, Human: 100%, Mouse: 83%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against ELAC2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ELAC2

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ELAC2

Target: ELAC2 (ElaC Homolog 2 (ELAC2))

Alternative Name: ELAC2

Background: The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein Interaction Partner: UBC, SUMO2, SUMO1, NEDD8, XPO5, SNX5, ARIH1, TNPO3, WDR4, IPO7, TSN, SARS, PPP2CB, PFDN1, NRD1, HARS, FEN1, FOXH1, SMAD3, SMAD2, COPS5, ASCC2, NDUFA7, GOLM1, CUX1, PUF60,
Protein Size: 501

Molecular Weight: 55 kDa

Gene ID: 60528