FGA antibody (N-Term)

Catalog No. ABIN2776977

This anti-FGA antibody is a Rabbit Polyclonal antibody detecting FGA in WB and IHC. Suitable for Human, Rat, Mouse, Cow, Dog, Goat, Pig, Sheep and Horse.

Quick Overview for FGA antibody (N-Term) (ABIN2776977)

Target: FGA (Fibrinogen alpha Chain (FGA))

Reactivity: Human, Rat, Mouse, Cow, Dog, Goat, Pig, Sheep, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-FGA Antibody

Binding Specificity: N-Term

Sequence: MFSMRIVCLV LSVVGTAWTA DSGEGDFLAE GGGVRGPRVV ERHQSACKDS

Predicted Reactivity: Cow: 93%, Dog: 86%, Goat: 91%, Horse: 85%, Human: 100%, Mouse: 86%, Pig: 93%, Rat: 91%, Sheep: 91%

Characteristics: This is a rabbit polyclonal antibody against FGA. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FGA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 644 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FGA

Target: FGA (Fibrinogen alpha Chain (FGA))

Alternative Name: FGA

Background: FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis.The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.
Alias Symbols: Fib2
Protein Interaction Partner: ASB7, ASB6, FN1, APOA1, ALB, UBC, SUMO2, MIS12, KHDRBS2, ITGA2B, SERPINA5, CDH5, SERPINF2, THBS1, F2, ITGB3, PLAT, HRG, PRRC2A, FGG, FGB, FGA, F13A1, NID1,
Protein Size: 644

Molecular Weight: 71 kDa

Gene ID: 2243

NCBI Accession: NM_021871, NP_068657

UniProt: Q4QQH7