GHRHR antibody (N-Term)

Catalog No. ABIN2777008

The Rabbit Polyclonal anti-GHRHR antibody has been validated for WB. It is suitable to detect GHRHR in samples from Human, Rat, Pig, Cow, Sheep, Dog, Rabbit, Horse and Guinea Pig.

Quick Overview for GHRHR antibody (N-Term) (ABIN2777008)

Target: GHRHR (Growth Hormone Releasing Hormone Receptor (GHRHR))

Reactivity: Human, Rat, Pig, Cow, Sheep, Dog, Rabbit, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GHRHR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GHRHR Antibody

Binding Specificity: N-Term

Sequence: VTLPCPDFFS HFSSESGAVK RDCTITGWSE PFPPYPVACP VPLELLAEEE

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 85%, Horse: 77%, Human: 100%, Pig: 86%, Rabbit: 79%, Rat: 93%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against GHRHR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GHRHR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 423 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GHRHR

Target: GHRHR (Growth Hormone Releasing Hormone Receptor (GHRHR))

Alternative Name: GHRHR

Background: GHRHR is a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in its gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature.This This gene, expressed in the pituitary, encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.
Alias Symbols: GHRFR, GHRHRpsv, GRFR, IGHD1B
Protein Interaction Partner: GHRH, GHRL, MLNR,
Protein Size: 423

Molecular Weight: 47 kDa

Gene ID: 2692

NCBI Accession: NM_000823, NP_000814

UniProt: Q02643

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Hormone Transport, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process