MAP4K6 antibody (Middle Region)

Catalog No. ABIN2777554

The Rabbit Polyclonal anti-MAP4K6 antibody (ABIN2777554) specifically detects MAP4K6 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Pig, Horse, Dog, Rabbit and Guinea Pig samples.

Quick Overview for MAP4K6 antibody (Middle Region) (ABIN2777554)

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Reactivity: Human, Mouse, Rat, Cow, Pig, Horse, Dog, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP4K6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAP4K6 Antibody

Binding Specificity: Middle Region

Sequence: PDSSPVLSPG NKAKPDDHRS RPGRPADFVL LKERTLDEAP RPPKKAMDYS

Predicted Reactivity: Cow: 85%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MINK1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MINK1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1312 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAP4K6

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Alternative Name: MINK1

Background: MINK1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways.This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.
Alias Symbols: B55, MAP4K6, MGC21111, MINK, YSK2, ZC3, hMINK, hMINKbeta
Protein Interaction Partner: UBC, HSP90AA1, NEDD4L, CASKIN1, SPTBN2, PKP4, ABI1, TUBA1B, KIFAP3, YWHAB, YWHAZ, NCK1, NEFM, MAP1B, CALM3, ACTA2,
Protein Size: 1312

Molecular Weight: 148 kDa

Gene ID: 50488

NCBI Accession: NM_001024937, NP_001020108

UniProt: Q5U8Z0

Pathways: Synaptic Membrane