MTA3 antibody (N-Term)

Catalog No. ABIN2777793

The Rabbit Polyclonal anti-MTA3 antibody has been validated for WB. It is suitable to detect MTA3 in samples from Human, Mouse, Rat, Cow, Horse, Rabbit and Dog.

Quick Overview for MTA3 antibody (N-Term) (ABIN2777793)

Target: MTA3 (Metastasis Associated 1 Family, Member 3 (MTA3))

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTA3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MTA3 Antibody

Binding Specificity: N-Term

Sequence: TLIMLADKHA KEIEEESETT VEADLTDKQK HQLKHRELFL SRQYESLPAT

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MTA3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human MTA1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MTA3

Target: MTA3 (Metastasis Associated 1 Family, Member 3 (MTA3))

Alternative Name: MTA3

Background: This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene.
Protein Size: 392

Molecular Weight: 43 kDa

Gene ID: 9112

NCBI Accession: NM_001203258, NP_001190187

Pathways: Chromatin Binding