SNRPB antibody (Middle Region)

Catalog No. ABIN2778832

This Rabbit Polyclonal antibody specifically detects SNRPB in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for SNRPB antibody (Middle Region) (ABIN2778832)

Target: SNRPB (Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNRPB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SNRPB Antibody

Binding Specificity: Middle Region

Sequence: LRGENLVSMT VEGPPPKDTG IARVPLAGAA GGPGIGRAAG RGIPAGVPMP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against SNRPB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SNRPB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 231 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SNRPB

Target: SNRPB (Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB))

Alternative Name: SNRPB

Background: SNRPB is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.
Alias Symbols: COD, SNRPB1, SmB/SmB', snRNP-B, SmB/B', Sm-B/B'
Protein Interaction Partner: RFX6, KRT40, L3MBTL3, GOLGA2, DAB1, TRIM23, CEP55, BANP, SS18L1, TFIP11, RBPMS, CD2BP2, CALCOCO2, HUWE1, PNMA1, PSMA3, UBC, LIN28A, MEPCE, RPA3, RPA2, RPA1, SF3A3, NCS1, CDKN2A, SRPK3, PRPF4B, SRPK2, SKIV2L, ICAM1, CD81, IGSF8, PAN2, Snrpc, LSM8, SNRPD3,
Protein Size: 231

Molecular Weight: 24 kDa

Gene ID: 6628

NCBI Accession: NM_003091, NP_003082

UniProt: Q66K91

Pathways: Ribonucleoprotein Complex Subunit Organization