KHSRP antibody (Middle Region)

Catalog No. ABIN405328

This Rabbit Polyclonal antibody specifically detects KHSRP in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit and Zebrafish (Danio rerio)and has been mentioned in 1 publication.

Quick Overview for KHSRP antibody (Middle Region) (ABIN405328)

Target: KHSRP (KH-Type Splicing Regulatory Protein (KHSRP))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KHSRP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-KHSRP Antibody

Binding Specificity: Middle Region

Sequence: WEEYYKKQAQ VATGGGPGAP PGSQPDYSAA WAEYYRQQAA YYGQTPGPGG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against KHSRP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human KHSRP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 711 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-KHSRP antibody (ABIN405328)

Ahn, Hwang, Liu, Wang, Zhang, Stephenson, Boronina, Cole, Dinkova-Kostova, Talalay, Cole: "Electrophilic tuning of the chemoprotective natural product sulforaphane." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 21, pp. 9590-5, (2010) (PubMed).

Target Details for KHSRP

Target: KHSRP (KH-Type Splicing Regulatory Protein (KHSRP))

Alternative Name: KHSRP

Background: KHSRP binds to the dendritic targeting element and may play a role in mRNA trafficking. It is part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. KHSRP mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. It may interact with single-stranded DNA from the far-upstream element (FUSE).It is also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
Alias Symbols: FBP2, FUBP2, KSRP, MGC99676
Protein Interaction Partner: HUWE1, Bace1, UBC, STAU1, LGR4, MDM2, WWOX, SUZ12, EED, RNF2, NAP1L4, HNRNPD, GFPT1, GARS, APBB1, ALDH16A1, TARDBP, CD81, MPG, UBL4A, WHSC1, VCAM1, ITGA4, FN1, STRIP1, ASF1B, CPLX1, CIRBP, SUMO1, RAE1, CAND1, COPS5, CUL1, CUL2, CUL3, CUL4B, CUL5, NEDD8, C
Protein Size: 711

Molecular Weight: 73 kDa

Gene ID: 8570

NCBI Accession: NM_003685, NP_003676

UniProt: Q92945