DIS3 antibody (N-Term)

Catalog No. ABIN2779073

This anti-DIS3 antibody is a Rabbit Polyclonal antibody detecting DIS3 in WB. Suitable for Human, Mouse, Rat, Cow, Rabbit, Dog, Horse, Guinea Pig and Pig.

Quick Overview for DIS3 antibody (N-Term) (ABIN2779073)

Target: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Horse, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIS3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DIS3 Antibody

Binding Specificity: N-Term

Sequence: DIVAVELLPK SQWVAPSSVV LHDEGQNEED VEKEEETERM LKTAVSEKML

Predicted Reactivity: Cow: 79%, Dog: 93%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 85%, Pig: 93%, Rabbit: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against DIS3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DIS3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 958 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DIS3

Target: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Alternative Name: DIS3

Background: DIS3, belonging to the ribonuclease II (RNB) family, has a 3'-5' exonuclease activity. It is a catalytic component of the exosome 3'->5' exoribonuclease complex required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and for mRNA decay. The protein is implicated in mitotic control and essential for cell division and spore germination. It may be involved in regulating protein dephosphorylation during mitosis.
Alias Symbols: DKFZp667L1817, FLJ10484, KIAA1008, MGC33035, RP11-342J4.3, RRP44, bA555G22.1, dis3p, EXOSC11
Protein Interaction Partner: SUMO2, UBC, TWF1, NTMT1, EXOSC8, EXOSC10, AICDA, WDR1, STXBP3, PPP5C, SH3PXD2B, EXOSC5, EXOSC4, EXOSC1, EXOSC3, SKIV2L2, EXOSC2, EXOSC7, DIS3, EXOSC9, CUL3, CUL5, SIRT7, BABAM1, EXOSC6, MPP6, ZBTB17,
Protein Size: 958

Molecular Weight: 109 kDa

Gene ID: 22894

NCBI Accession: NM_014953, NP_055768

UniProt: Q9Y2L1