XRN1 antibody (Middle Region)

Catalog No. ABIN2779146

This Rabbit Polyclonal antibody specifically detects XRN1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Pig, Rabbit and Saccharomyces cerevisiae.

Quick Overview for XRN1 antibody (Middle Region) (ABIN2779146)

Target: XRN1 (5'-3' Exoribonuclease 1 (XRN1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XRN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-XRN1 Antibody

Binding Specificity: Middle Region

Sequence: LPQEISQVNQ HHKSGFNDNS VKYQQRKHDP HRKFKEECKS PKAECWSQKM

Predicted Reactivity: Cow: 92%, Dog: 93%, Guinea Pig: 79%, Horse: 90%, Human: 100%, Mouse: 86%, Pig: 85%, Rabbit: 100%, Rat: 100%, Yeast: 90%

Characteristics: This is a rabbit polyclonal antibody against XRN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human XRN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1706 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for XRN1

Target: XRN1 (5'-3' Exoribonuclease 1 (XRN1))

Alternative Name: XRN1

Background: SEP1 (XRN1) localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-67 BX640905.1 1-67 68-5188 AY137776.1 1-5121 5189-5269 BG197321.1 308-388 5270-10092 AC023508.16 31718-36540 c
Alias Symbols: DKFZp434P0721, DKFZp686B22225, DKFZp686F19113, FLJ41903, SEP1
Protein Interaction Partner: ZFP36, UBC, RPA3, RPA2, RPA1, BMI1, HECW2, HERC2P4, RNF187, B3GALT6, EXOSC6, C1orf85, VWA5B2, MFSD5, PRADC1, ANGPTL6, PLEKHG2, SPATA20, C1GALT1, DCP1A, HEATR1, NDUFA13, EXOSC1, DPP7, RBMX, MTCH2, TMEM50A, CD97, ATP5G2, SNHG1, LINC01541, DCP1B, SRRM2, SKIV
Protein Size: 1706

Molecular Weight: 194 kDa

Gene ID: 54464

NCBI Accession: NM_019001, NP_061874

UniProt: Q8IZH2