SNW1 antibody (N-Term)

Catalog No. ABIN182523

This anti-SNW1 antibody is a Rabbit Polyclonal antibody detecting SNW1 in WB and IHC. Suitable for Human, Mouse, Dog, Cow, Horse, Pig, Rabbit, Rat, Guinea Pig and Saccharomyces cerevisiae.

Quick Overview for SNW1 antibody (N-Term) (ABIN182523)

Target: SNW1 (SNW Domain Containing 1 (SNW1))

Reactivity: Human, Mouse, Dog, Cow, Horse, Pig, Rabbit, Rat, Guinea Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNW1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SNW1 Antibody

Binding Specificity: N-Term

Sequence: RQGQSKDKVI YSKYTDLVPK EVMNADDPDL QRPDEEAIKE ITEKTRVALE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 83%

Characteristics: This is a rabbit polyclonal antibody against SKIIP. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SKIIP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 536 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SNW1

Target: SNW1 (SNW Domain Containing 1 (SNW1))

Alternative Name: SKIIP

Background: SKIIP (Nuclear Protein SkiP, nuclear receptor coactivator NCoA-62, ski-interacting protein) is a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also interact with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
Alias Symbols: Bx42, SKIP, Prp45, SKIIP, PRPF45, NCOA-62
Protein Interaction Partner: TRAF1, GOLGA2, KRT40, LZTS2, RINT1, TEX11, CEP55, PPIL1, TFIP11, MTUS2, IKZF1, TP53, TUBGCP3, AURKB, UBC, SUZ12, RNF2, BMI1, HECW2, HDAC11, Dlg4, TTC14, ZNF830, SNIP1, CXorf56, XAB2, CTNNBL1, SART1, NHP2L1, MFAP1, EIF4A3, MAGOH, DHX15, DDX5, PABPC1, SKIV2
Protein Size: 536

Molecular Weight: 61 kDa

Gene ID: 22938

NCBI Accession: NM_012245, NP_036377

UniProt: Q13573

Pathways: Retinoic Acid Receptor Signaling Pathway