c-FOS antibody (Middle Region)

Catalog No. ABIN2779690

The Rabbit Polyclonal anti-c-FOS antibody has been validated for WB. It is suitable to detect c-FOS in samples from Human, Rat, Mouse, Cow, Pig, Dog, Sheep, Horse, Rabbit and Guinea Pig.

Quick Overview for c-FOS antibody (Middle Region) (ABIN2779690)

Target: c-FOS (c-Fos) (c-Fos)

Reactivity: Human, Rat, Mouse, Cow, Pig, Dog, Sheep, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-FOS antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-c-FOS Antibody

Binding Specificity: Middle Region

Sequence: PSVEPVKSIS SMELKTEPFD DFLFPASSRP SGSETARSVP DMDLSGSFYA

Predicted Reactivity: Cow: 79%, Dog: 93%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against FOS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FOS

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 380 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for c-FOS

Target: c-FOS (c-Fos) (c-Fos)

Alternative Name: FOS

Background: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: c-fos, p55, AP-1, C-FOS
Protein Interaction Partner: Psma4, CENPO, LMO3, ARFGAP1, USF2, USF1, PSMC5, PRKAA2, JUNB, JUN, GNG11, NQO1, ATF2, AQP1, LUZP4, CYTH4, CREB5, ABL1, CLU, ATP5I, APP, MTERF4, ANP32E, ARL6IP4, COPS4, CABP1, ZNF133, SET, NEFM, MAP1B, JUND, HSPA1A, MAF, FOS, DDIT3, CEBPG, CEBPE, CEBPA, AT
Protein Size: 380

Molecular Weight: 41 kDa

Gene ID: 2353

NCBI Accession: NM_005252, NP_005243

UniProt: P01100

Pathways: S100 Proteins