FOXP1 antibody (N-Term)

Catalog No. ABIN2779725

This Rabbit Polyclonal antibody specifically detects FOXP1 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Cow, Dog, Horse and Guinea Pig and has been mentioned in 3+ publications.

Quick Overview for FOXP1 antibody (N-Term) (ABIN2779725)

Target: FOXP1 (Forkhead Box P1 (FOXP1))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-FOXP1 Antibody

Binding Specificity: N-Term

Sequence: MIPTELQQLW KEVTSAHTAE ETTGNNHSSL DLTTTCVSSS APSKTSLI

Predicted Reactivity: Cow: 92%, Dog: 85%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against FOXP1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FOXP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 677 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FOXP1 antibody (ABIN2779725)

Tang, Becanovic, Desplats, Spencer, Hill, Connolly, Masliah, Leavitt, Thomas: "Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease." in: Human molecular genetics, Vol. 21, Issue 14, pp. 3097-111, (2012) (PubMed).

Konstantoulas, Parmar, Li: "FoxP1 promotes midbrain identity in embryonic stem cell-derived dopamine neurons by regulating Pitx3." in: Journal of neurochemistry, Vol. 113, Issue 4, pp. 836-47, (2010) (PubMed).

Jepsen, Gleiberman, Shi, Simon, Rosenfeld: "Cooperative regulation in development by SMRT and FOXP1." in: Genes & development, Vol. 22, Issue 6, pp. 740-5, (2008) (PubMed).

Target Details for FOXP1

Target: FOXP1 (Forkhead Box P1 (FOXP1))

Alternative Name: FOXP1

Background: FOXP1 belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s).
Alias Symbols: QRF1, 12CC4, hFKH1B, HSPC215
Protein Interaction Partner: SUMO2, MYC, IL3RA, ELAVL1, NCOR2, GATAD2B, MTA1, FOXP1, FOXP4, FOXP2, CTBP1,
Protein Size: 677

Molecular Weight: 75 kDa

Gene ID: 27086

NCBI Accession: NM_032682, NP_116071

UniProt: Q9H334

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response