ZBTB33 antibody (N-Term)

Catalog No. ABIN2780808

This Rabbit Polyclonal antibody specifically detects ZBTB33 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig and Rabbit.

Quick Overview for ZBTB33 antibody (N-Term) (ABIN2780808)

Target: ZBTB33 (Zinc Finger and BTB Domain Containing 33 (ZBTB33))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZBTB33 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ZBTB33 Antibody

Binding Specificity: N-Term

Sequence: MESRKLISAT DIQYSGSLLN SLNEQRGHGL FCDVTVIVED RKFRAHKNIL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against ZBTB33. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ZBTB33

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 672 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ZBTB33

Target: ZBTB33 (Zinc Finger and BTB Domain Containing 33 (ZBTB33))

Alternative Name: ZBTB33

Background: ZBTB33 is a transcriptional regulator with bimodal DNA-binding specificity. ZBTB33 binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. ZBTB33 recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway. It may also activate transcription of a subset of target genes by the recruitment of CTNND2.
Alias Symbols: ZNF348, ZNF-kaiso
Protein Interaction Partner: HUWE1, SUMO2, SUMO3, CBFA2T3, LMNA, UBC, TCF7L2, KPNA2, CTNND1, CTNNB1, CTCF, ELAVL1, CTNND2, WDR48, NCOR1, ZBTB33, HDAC3, WNT11, S100A4, MMP7,
Protein Size: 672

Molecular Weight: 74 kDa

Gene ID: 10009

NCBI Accession: NM_006777, NP_006768

UniProt: Q86T24