BCL11A antibody (C-Term)

Catalog No. ABIN2781193

This anti-BCL11A antibody is a Rabbit Polyclonal antibody detecting BCL11A in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for BCL11A antibody (C-Term) (ABIN2781193)

Target: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL11A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BCL11A Antibody

Binding Specificity: C-Term

Sequence: YACAQSSKLT RHMKTHGQVG KDVYKCEICK MPFSVYSTLE KHMKKWHSDR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against BCL11A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human BCL11A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 835 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BCL11A

Target: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Alternative Name: BCL11A

Background: BCL11A is a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression.
Alias Symbols: BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, EVI9, FLJ10173, FLJ34997, HBFQTL5, KIAA1809, ZNF856
Protein Interaction Partner: GMCL1P1, ZBTB24, NCK2, LMO1, NR2E3, NR2E1, NR2F2, NR2F1, NR2F6, HDAC2, HDAC1, CDCA3, YME1L1, CDK6, CDK4, ACTC1, APP, UBC, BCL6, BCL11A, Sumo1, SUMO2, SUMO3, SIRT1, MBD3, MTA2, MTA1, CHD4,
Protein Size: 835

Molecular Weight: 91 kDa

Gene ID: 53335

NCBI Accession: NM_022893, NP_075044

UniProt: Q9H165

Pathways: Regulation of Cell Size