IRF6 antibody (C-Term)

Catalog No. ABIN2781490

The Rabbit Polyclonal anti-IRF6 antibody has been validated for WB. It is suitable to detect IRF6 in samples from Human, Mouse, Rat, Dog, Rabbit, Cow, Horse, Guinea Pig and Sheep.

Quick Overview for IRF6 antibody (C-Term) (ABIN2781490)

Target: IRF6 (Interferon Regulatory Factor 6 (IRF6))

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Horse, Guinea Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IRF6 Antibody

Binding Specificity: C-Term

Sequence: FLSDLIAHQK GQIEKQPPFE IYLCFGEEWP DGKPLERKLI LVQVIPVVAR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against IRF6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human IRF6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 591 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IRF6

Target: IRF6 (Interferon Regulatory Factor 6 (IRF6))

Alternative Name: IRF6

Background: IRF6 is a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in its gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation.The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
Alias Symbols: LPS, OFC6, PIT, PPS, VWS, VWS1
Protein Interaction Partner: HHV8GK18_gp81, UBC, BNC2, IRF5, IRF8, ZBTB3, RFX3, TLX2, LBP,
Protein Size: 591

Molecular Weight: 65 kDa

Gene ID: 3664

NCBI Accession: NM_004661, NP_006138

UniProt: O14896