KNG1 antibody (Middle Region)

Catalog No. ABIN2782314

The Rabbit Polyclonal anti-KNG1 antibody has been validated for WB. It is suitable to detect KNG1 in samples from Human, Mouse, Pig and Horse. There is 1 publication available.

Quick Overview for KNG1 antibody (Middle Region) (ABIN2782314)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human, Mouse, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNG1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KNG1 Antibody

Binding Specificity: Middle Region

Sequence: YPGKDFVQPP TKICVGCPRD IPTNSPELEE TLTHTITKLN AENNATFYFK

Predicted Reactivity: Horse: 85%, Human: 100%, Mouse: 77%, Pig: 92%

Characteristics: This is a rabbit polyclonal antibody against KNG1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KNG1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 644 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-KNG1 antibody (ABIN2782314)

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: KNG1

Background: Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII and inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. The active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects such as influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis, etc.
Alias Symbols: BDK, KNG
Protein Interaction Partner: Ance, ECE1, COPS6, RXFP4, CPN1, F11, HABP2, CTSK, PREP, MEP1A, ITGB2, GP1BA, KLKB1, KNG1, VTN, THBS1, F2, PLAUR, PLG, KLK1, KRT1, FTL, ELANE, CD93, CTSL, CTSS, CTSG, CAPN2, CAPN1, AGT, APP,
Protein Size: 644

Molecular Weight: 72 kDa

Gene ID: 3827

NCBI Accession: NM_001102416, NP_001095886

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process