SOD1 antibody (N-Term)

Catalog No. ABIN2782351

Product Details anti-SOD1 Antibody

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MATKAVCVLK GDGPVQGIIN FEQKESNGPV KVWGSIKGLT EGLHGFHVHE

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against SOD1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SOD1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 154 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SOD1 antibody (ABIN2782351)

Hays, Naini, He, Mitsumoto, Rowland: "Sporadic amyotrophic lateral sclerosis and breast cancer: Hyaline conglomerate inclusions lead to identification of SOD1 mutation." in: Journal of the neurological sciences, Vol. 242, Issue 1-2, pp. 67-9, (2006) (PubMed).

Target Details for SOD1

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Alternative Name: SOD1 (SOD1 Products)

Background: SOD1 binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in its gene have been implicated as causes of familial amyotrophic lateral sclerosis.The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
Alias Symbols: ALS, ALS1, IPOA, SOD, homodimer, hSod1
Protein Interaction Partner: SOD1, CRYAB, UBC, SMAD2, HDAC6, GSH1, OPTN, PRDX5, AHCYL1, TIAL1, PRDX2, SPTBN1, SOD2, PPP2CA, PPIA, PLS3, PRDX1, NME2, NME1, Hspa4l, Hspa4, Hspa2, Hspa1b, Hsph1, Dnaja1, Hspa8, Hspa5, Ccs, UBE3A, COMMD1, Stub1, SUMO4, DYNLT1, AMFR, MARCH5, RNF19A, PSMD4,
Protein Size: 154

Molecular Weight: 16 kDa

Gene ID: 6647

NCBI Accession: NM_000454, NP_000445

UniProt: P00441

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis