DCC antibody (Middle Region)

Catalog No. ABIN2782671

Product Details anti-DCC Antibody

Target: DCC (Deleted in Colorectal Carcinoma (DCC))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCC antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PIGQMHPPHG SVTPQKNSNL LVIIVVTVGV ITVLVVVIVA VICTRRSSAQ

Predicted Reactivity: Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against DCC. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DCC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1447 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DCC

Target: DCC (Deleted in Colorectal Carcinoma (DCC))

Alternative Name: DCC (DCC Products)

Background: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Alias Symbols: CRC18, CRCR1, IGDCC1
Protein Interaction Partner: UBC, ALB, BARD1, sina, UBI4, SIAH2, EIF4E3, EIF2A, EIF5A2, NTN1, RPL23, EIF2S2, EIF2B2, EIF2B4, EZR, RPS24, RPS13, RPS10, RPS6, RPS4X, RPL38, RPL28, RPL13, RPL5, PTK2, MAPK1, RPL10A, EIF3E, EIF4E, EIF2S3, EIF2B1, EIF1AX, ADORA2B, APPL1, CASP9, SIAH1, MAPK
Protein Size: 1447

Molecular Weight: 158 kDa

Gene ID: 1630

NCBI Accession: NM_005215, NP_005206

UniProt: P43146

Pathways: Regulation of Cell Size