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DCC Products

(Deleted in Colorectal Carcinoma (DCC))
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009].

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Featured DCC Categories

DCC Antibodies

High quality antibodies with extensive validation data.

DCC ELISA Kits

Reliable ELISA kits for a wide range of species.

DCC Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DCC Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), WB
Validations
  • (3)
Cat. No. ABIN3030709
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7190434
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), WB
Validations
  • (2)
Cat. No. ABIN3044119
Quantity 100 μg
Datasheet Datasheet

Recommended DCC ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966310
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730147
Quantity 96 tests
Datasheet Datasheet

Recommended DCC Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3078676
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3120923
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134627
Quantity 0.25 mg
Datasheet Datasheet

Latest Publications for our DCC products

Zhang, Mi, Hao, Fan, Gao: "Progesterone down-regulates SLIT/ROBO expression in mouse corpus luteum." in: Acta histochemica, Vol. 119, Issue 7, pp. 740-746, (2017) (PubMed).

Huang, Chu, Hwang, Tsaur: "Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain." in: The Journal of comparative neurology, Vol. 520, Issue 16, pp. 3650-72, (2012) (PubMed).

Shibata, Reale, Lavin, Silverman, Fearon, Steele, Jessup, Loda, Summerhayes: "The DCC protein and prognosis in colorectal cancer." in: The New England journal of medicine, Vol. 335, Issue 23, pp. 1727-32, (1996) (PubMed).

Reale, Hu, Zafar, Getzenberg, Levine, Fearon: "Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues." in: Cancer research, Vol. 54, Issue 16, pp. 4493-501, (1994) (PubMed).

Fearon, Cho, Nigro, Kern, Simons, Ruppert, Hamilton, Preisinger, Thomas, Kinzler: "Identification of a chromosome 18q gene that is altered in colorectal cancers." in: Science (New York, N.Y.), Vol. 247, Issue 4938, pp. 49-56, (1990) (PubMed).

Vogelstein, Fearon, Hamilton, Kern, Preisinger, Leppert, Nakamura, White, Smits, Bos: "Genetic alterations during colorectal-tumor development." in: The New England journal of medicine, Vol. 319, Issue 9, pp. 525-32, (1988) (PubMed).

Fearon, Hamilton, Vogelstein: "Clonal analysis of human colorectal tumors." in: Science (New York, N.Y.), Vol. 238, Issue 4824, pp. 193-7, (1987) (PubMed).

Synonyms and alternative names related to DCC

DCC netrin 1 receptor (DCC), DCC netrin 1 receptor (dcc), deleted in colorectal carcinoma (Dcc), deleted in colorectal carcinoma (dcc), DCC netrin 1 receptor (Dcc), netrin receptor DCC (LOC100712666), C030036D22Rik, CRC18, CRCR1, DCC, Dcc, dcca-A, IGDCC1, Igdcc1, MRMV1, xdcc, XDCCa, zdcc

Protein level used designations for DCC

  • colorectal cancer suppressor
  • colorectal tumor suppressor
  • deleted in colorectal cancer protein
  • immunoglobulin superfamily DCC subclass member 1
  • immunoglobulin superfamily, DCC subclass, member 1
  • netrin receptor DCC
  • tumor suppressor protein DCC
  • deleted in colorectal carcinoma
  • deleted in colorectal cancer
  • deleted in colorectal cancer tumor suppressor
  • netrin receptor DCC-like
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