Corin antibody (C-Term)

Catalog No. ABIN2782724

The Rabbit Polyclonal anti-Corin antibody has been validated for WB. It is suitable to detect Corin in samples from Human, Rat, Mouse, Cow, Horse, Guinea Pig, Rabbit, Dog and Zebrafish (Danio rerio).

Quick Overview for Corin antibody (C-Term) (ABIN2782724)

Target: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Reactivity: Human, Rat, Mouse, Cow, Horse, Guinea Pig, Rabbit, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Corin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Corin Antibody

Binding Specificity: C-Term

Sequence: MGNKMPFKLQ EGEVRIIPLE QCQSYFDMKT ITNRMICAGY ESGTVDSCMG

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Corin. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Corin

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1113 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Corin

Target: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Alternative Name: Corin

Background: Corin is a Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. It converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Corin also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
Alias Symbols: AV273130, Lrp4
Protein Size: 1113

Molecular Weight: 123 kDa

Gene ID: 53419

NCBI Accession: NM_016869, NP_058565

UniProt: Q9Z319

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones