COQ8A antibody (N-Term)

Catalog No. ABIN2783345

This Rabbit Polyclonal antibody specifically detects COQ8A in WB. It exhibits reactivity toward Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio)and has been mentioned in 1 publication.

Quick Overview for COQ8A antibody (N-Term) (ABIN2783345)

Target: COQ8A (Coenzyme Q8A (COQ8A))

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COQ8A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COQ8A Antibody

Binding Specificity: N-Term

Sequence: FANPRDSFSA MGFQRRFFHQ DQSPVGGLTA EDIEKARQAK ARPENKQHKQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 90%

Characteristics: This is a rabbit polyclonal antibody against CABC1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CABC1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 647 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-COQ8A antibody (ABIN2783345)

Lagier-Tourenne, Tazir, López, Quinzii, Assoum, Drouot, Busso, Makri, Ali-Pacha, Benhassine, Anheim, Lynch, Thibault, Plewniak, Bianchetti, Tranchant, Poch, DiMauro, Mandel, Barros, Hirano, Koenig: "ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency." in: American journal of human genetics, Vol. 82, Issue 3, pp. 661-72, (2008) (PubMed).

Target Details for COQ8A

Target: COQ8A (Coenzyme Q8A (COQ8A))

Alternative Name: CABC1

Background: CABC1 is a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis.This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found, however, their full-length nature has not been determined.
Alias Symbols: ADCK3, COQ8, MGC4849, ARCA2, CABC1, SCAR9
Protein Interaction Partner: TMEM239, REEP6, TMEM159, AGTRAP, TFIP11, RABAC1, VCP, UBC, IRAK2, IRAK1, ICT1, COQ8,
Protein Size: 647

Molecular Weight: 72 kDa

Gene ID: 56997

NCBI Accession: NM_020247, NP_064632

UniProt: Q8NI60