GSTA3 antibody (Middle Region)

Catalog No. ABIN2783389

This Rabbit Polyclonal antibody specifically detects GSTA3 in WB. It exhibits reactivity toward Human, Mouse and Sheep.

Quick Overview for GSTA3 antibody (Middle Region) (ABIN2783389)

Target: GSTA3 (Glutathione S-Transferase alpha 3 (GSTA3))

Reactivity: Human, Mouse, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSTA3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GSTA3 Antibody

Binding Specificity: Middle Region

Sequence: SSLISNFPLL KALKTRISNL PTVKKFLQPG SPRKPPADAK ALEEARKIFR

Predicted Reactivity: Human: 100%, Mouse: 79%, Sheep: 77%

Characteristics: This is a rabbit polyclonal antibody against GSTA3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GSTA3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 222 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GSTA3

Target: GSTA3 (Glutathione S-Transferase alpha 3 (GSTA3))

Alternative Name: GSTA3

Background: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.
Alias Symbols: GSTA3-3, GTA3, MGC22232
Protein Interaction Partner: BAG3, APP,
Protein Size: 222

Molecular Weight: 25 kDa

Gene ID: 2940

NCBI Accession: NM_000847, NP_000838

UniProt: Q16772