PARK7/DJ1 antibody (C-Term)

Catalog No. ABIN2784491

This anti-PARK7/DJ1 antibody is a Rabbit Polyclonal antibody detecting PARK7/DJ1 in WB and IHC. Suitable for Human, Mouse, Rat, Cow, Pig, Dog, Horse, Guinea Pig and Rabbit.

Quick Overview for PARK7/DJ1 antibody (C-Term) (ABIN2784491)

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARK7/DJ1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PARK7/DJ1 Antibody

Binding Specificity: C-Term

Sequence: TYSENRVEKD GLILTSRGPG TSFEFALAIV EALNGKEVAA QVKAPLVLKD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PARK7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PARK7

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 189 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PARK7/DJ1

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Alternative Name: PARK7

Background: PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7.The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
Alias Symbols: DJ-1, DJ1, FLJ27376
Protein Interaction Partner: GOPC, VHL, UBC, PARK7, NPM1, BBS1, SNCA, Bax, HIPK1, TDP2, PRDX5, PPARGC1A, FADD, PRDX2, TALDO1, SREBF2, SFPQ, PTEN, NONO, MAP3K5, HSPA4, CASP8, BAG1, ATP5J, AR, PINK1, TP53, SLC18A2, PARK2, NDUFS3, NDUFA4, ND1, MAP1B, CSN1S1, SUMO1, UBE2I, DAXX, UBA2, BC
Protein Size: 189

Molecular Weight: 20 kDa

Gene ID: 11315

NCBI Accession: NM_007262, NP_009193

UniProt: Q99497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport