PAXIP1 antibody (N-Term)

Catalog No. ABIN2784556

The Rabbit Polyclonal anti-PAXIP1 antibody has been validated for WB. It is suitable to detect PAXIP1 in samples from Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Guinea Pig, Horse and Rabbit.

Quick Overview for PAXIP1 antibody (N-Term) (ABIN2784556)

Target: PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAXIP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PAXIP1 Antibody

Binding Specificity: N-Term

Sequence: MFDDSSDSSP EKQERNLNWT PAEVPQLAAA KRRLPQGKEP GLINLCANVP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against PAXIP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PAXIP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 697 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PAXIP1

Target: PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))

Alternative Name: PAXIP1

Background: PAXIP1 functions as a key component of the DNA damage response, and phosphoserine or phosphothreonine-specific binding modules. PAXIP1 recognizes substrates phosphorylated by the kinases ataxia telangiectasia-mutated (ATM), ataxia telangiectasia and RAD3-related (ATR) in response to gamma irradiation. It may play a role in PAX2-dependent transcriptional regulation. PAXIP1 plays a role in early development, most probably in cell proliferation.
Alias Symbols: PTIP, TNRC2, CAGF28, CAGF29, PACIP1, PAXIP1L, FLJ41049
Protein Interaction Partner: MAPRE2, POM121, NXT1, PPARG, XAGE1E, SMAD2, SPATA18, COMTD1, BTBD16, DIS3L, LACTB, HNRNPLL, ZNF251, ZNF622, BTBD6, C7orf50, FAM175A, TMEM120A, FAHD1, TM2D3, ATHL1, CENPU, DYNC2H1, BRCC3, KRI1, ANAPC1, NOM1, POLR1E, NCAPG, AASDHPPT, RBM25, CATSPERG, WDR48,
Protein Size: 697

Molecular Weight: 74 kDa

Gene ID: 22976

NCBI Accession: NM_007349

UniProt: Q6ZW49

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response