DYNC1I2 antibody (N-Term)

Catalog No. ABIN2784706

The Rabbit Polyclonal anti-DYNC1I2 antibody has been validated for WB. It is suitable to detect DYNC1I2 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Rabbit.

Quick Overview for DYNC1I2 antibody (N-Term) (ABIN2784706)

Target: DYNC1I2 (Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYNC1I2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DYNC1I2 Antibody

Binding Specificity: N-Term

Sequence: VAPKPPIEPE EEKTLKKDEE NDSKAPPHEL TEEEKQQILH SEEFLSFFDH

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against DYNC1I2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DYNC1I2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 638 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DYNC1I2

Target: DYNC1I2 (Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2))

Alternative Name: DYNC1I2

Background: DYNC1I2 acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
Alias Symbols: DNCI2, FLJ21089, FLJ90842, IC2, MGC104199, MGC111094, MGC9324
Protein Interaction Partner: DYNLRB1, TUBGCP3, SUMO2, UBC, RNF2, EIF3CL, PRUNE2, DYNC1LI1, EIF3K, SERBP1, HNRNPA0, AKAP12, EIF3G, EIF3B, EIF3A, RPS26, RPS13, RPS5, PSMD8, PSMC5, YBX1, MAP2, DYNC1LI2, DYNC1H1, DDX1, ABCF1, vpr, PEX14, VCP, ECT2, CUL3, Dynll1, Dync1i2, SRRM2, DCTN1, PN
Protein Size: 638

Molecular Weight: 71 kDa

Gene ID: 1781

NCBI Accession: NM_001378, NP_001369

UniProt: Q13409

Pathways: M Phase