CSH1 antibody (Middle Region)

Catalog No. ABIN2784912

The Rabbit Polyclonal anti-CSH1 antibody has been validated for WB. It is suitable to detect CSH1 in samples from Human, Mouse, Rat, Dog, Guinea Pig, Rabbit, Cow, Goat, Horse, Pig and Sheep.

Quick Overview for CSH1 antibody (Middle Region) (ABIN2784912)

Target: CSH1 (Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Rabbit, Cow, Goat, Horse, Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSH1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CSH1 Antibody

Binding Specificity: Middle Region

Sequence: LFDHAMLQAH RAHQLAIDTY QEFRLEDGSR RTGQILKQTY SKFDTNSHNH

Predicted Reactivity: Cow: 79%, Dog: 86%, Goat: 90%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 86%, Rabbit: 79%, Rat: 86%, Sheep: 90%

Characteristics: This is a rabbit polyclonal antibody against CSH2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CSH2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 122 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CSH1

Target: CSH1 (Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1))

Alternative Name: CSH2

Background: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity.
Alias Symbols: CS-2, CSB, hCS-B
Protein Interaction Partner: PTPN12, SMAD9, SMAD4, SMAD3, SMAD2, POLR2A,
Protein Size: 122

Molecular Weight: 14 kDa

Gene ID: 1443

NCBI Accession: NM_022645, NP_072171

UniProt: B1A4H9

Pathways: Response to Growth Hormone Stimulus