Ensa antibody (N-Term)

Catalog No. ABIN2785426

This anti-Ensa antibody is a Rabbit Polyclonal antibody detecting Ensa in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Horse, Pig and Rabbit.

Quick Overview for Ensa antibody (N-Term) (ABIN2785426)

Target: Ensa (ENSA) (Endosulfine alpha (ENSA))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ensa antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Ensa Antibody

Binding Specificity: N-Term

Sequence: MAGGLGCDVC YWFVEDTQEK EGILPERAEE AKLKAKYPSL GQKPGGSDFL

Predicted Reactivity: Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against ENSA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ENSA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 113 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Ensa

Target: Ensa (ENSA) (Endosulfine alpha (ENSA))

Alternative Name: ENSA

Background: The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: MGC4319, MGC78563, MGC8394, ARPP-19e
Protein Interaction Partner: UBC, SNCA, PSEN1, ACD, POT1, RAP2A, RIM15, KCTD15, ARIH2, ABCC8, ENO2, MCM3,
Protein Size: 113

Molecular Weight: 12 kDa

Gene ID: 2029

NCBI Accession: NM_207047, NP_996930

UniProt: O43768