Coilin antibody (C-Term)

Catalog No. ABIN2785484

This anti-Coilin antibody is a Rabbit Polyclonal antibody detecting Coilin in WB. Suitable for Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse and Rabbit.

Quick Overview for Coilin antibody (C-Term) (ABIN2785484)

Target: Coilin (COIL)

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Coilin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Coilin Antibody

Binding Specificity: C-Term

Sequence: DYSLLPLLAA APQVGEKIAF KLLELTSSYS PDVSDYKEGR ILSHNPETQQ

Predicted Reactivity: Cow: 93%, Dog: 92%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%, Zebrafish: 82%

Characteristics: This is a rabbit polyclonal antibody against COIL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human COIL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 576 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Coilin

Target: Coilin (COIL)

Alternative Name: COIL

Background: COIL is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies.The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CLN80, p80-coilin
Protein Interaction Partner: MFAP1, FGF12, BYSL, WDR34, ZCCHC10, ARMCX1, ZNF277, PDLIM5, CDC23, SNRPF, PTS, POLR2L, PDE4D, DRG1, WWOX, UBL5, CSNK2A2, UBC, VCP, TAF9, LACTB2, KYNU, SMN2, SMN1, GTF2F1, APP, UBD, PLEKHG4, KAZN, PSME3, FAM115A, SART3, PREPL, FXR2, PICK1, FHL5, DNAJA3, KA
Protein Size: 576

Molecular Weight: 63 kDa

Gene ID: 8161

NCBI Accession: NM_004645, NP_004636

UniProt: P38432

Pathways: Ribonucleoprotein Complex Subunit Organization